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02-Pharmacology

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Antifungals

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Antifungal overview

Antifungal overview

May 08, 20251 min read

Treatments of choice for
Invasive candidiasis
Cryptococcal meningitis
Invasive aspergillosis
Mucocutaneous candidiasis

Antifungal mechanisms of action
Echinocandins (-fungin)
Cyclic lipopeptides that non-competitively inhibit 1,3 -b-D glucan synthase (Fungal Cell Wall)
Systemic Azoles
Fungal CYP-450 Inhibitor (also inhibits human CYP!!)

Common adverse effects of antifungals


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